Introduction to the effects of CBD in the disease of the Parkinson. Several studies indicate that a stimulation of the Endocannabinoid System potentially promotes neuroprotective effects capable of slowing neuronal loss in Parkinson's disease.
CBD and Parkinson's disease
The Parkinson's disease is a neurodegenerative disorder that can appear in adulthood and significantly affects the quality of life and progressively impairs the autonomy of the sufferer. The cause of the disease is unknown, but it is thought to result from a combination of different environmental and genetic factors. It is characterised by degeneration and loss of dopaminergic neurons in the substantia nigra of the brain, affecting the basal ganglia, and the appearance of intracellular inclusions called Lewy bodies. Common symptoms include akinesia or slowness of movement, resting tremor, muscle rigidity, gait and postural stability problems, motor fluctuations, apathy, depression, sleep disorders, cognitive impairment, autonomic dysfunction, neuropsychiatric disorders, digestive problems and sensory disturbances.
The diagnosis is performed by observation of specific motor signs and symptoms and complementary tests to rule out other types of Parkinsonism, in addition to anamnesis and a thorough neurological examination. At present, there is no curative treatment for Parkinson's disease, but drugs are effective at a symptomatic level, particularly Levodopa, the effect of which causes alternating fluctuations depending on how well or poorly the symptoms are controlled, known as "On-Off". In addition to pharmacological treatment, physiotherapy activities can be a positive factor both symptomatically and in terms of improving quality of life.
The Endocannabinoid System is our physiological system for maintaining the body's balance and its presence is particularly evident in the central nervous system, where it maintains a close relationship with the basal ganglia. Several studies have shown that stimulation of the endocannabinoid system promotes neuroprotective effects capable of slowing neuronal loss in Parkinson's disease. In particular, the CBD is being studied for its neuromodulatory activity, in terms of improving and increasing the quality of nerve transmissions.
Types of Parkinson's disease
Generally, the types of Parkinson's are classified as follows tremor which has a better prognosis and the ways non-tremoric (stiff-kinetic and gait instability/disorder), together with a mixed subgroup.
CBD and Parkinson's: Fact or myth?
CBD could represent a valid alternative to alleviate Parkinson's symptoms due to its therapeutic properties and effects, such as the neuroprotective effect, which favours different neuroprotective mechanisms against inflammation and oxidative stress that favour motor and cognitive functions, and the neuromodulatory effect, which improves and increases the quality of nerve transmissions. However, more research is still needed to determine the efficacy and safety of CBD in the treatment of Parkinson's disease.
This blog is about Parkinson's disease, a complex and heterogeneous neurodegenerative disorder that significantly affects the quality of life and autonomy of people who suffer from it. It is the second most common neurodegenerative disorder after Alzheimer's disease and affects mostly males. The overall prevalence is 0.3%, increasing to 1% in people over 60 years of age. In addition, it has been observed that 83% of patients 20 years after suffering from the disease develop some form of dementia.
Diagnosis and Treatment of Parkinson's disease
Parkinson's disease is caused by the degeneration and loss of dopaminergic neurons in the substantia nigra of the brain affecting the basal ganglia. The aetiology is unknown, but may result from a combination of different environmental and genetic factors. Intracellular inclusions called Lewy bodies are observed. In addition, it has been observed that neuronal inflammation and oxidative stress may contribute to the onset of the disease.
Clinical signs and symptoms of Parkinson's include motor manifestations such as akinesia or slowness of movement (the main symptom), resting tremor, muscle rigidity, gait and postural stability problems, and motor fluctuations such as dyskinesias (involuntary movements) and dystonia (muscle contractions). Non-motor manifestations include apathy, depression, sleep disturbances, cognitive impairment, autonomic dysfunction, neuropsychiatric disorders, digestive problems and sensory disturbances.
Cannabidiol (CBD), a non-psychoactive compound found in the cannabis plant, has been studied in relation to Parkinson's disease. It has been shown that CBD can act as a neuroprotective and anti-inflammatory agent, reduce muscle stiffness and improve sleep quality in Parkinson's patients. Although further studies are needed to determine the efficacy of CBD in the treatment of Parkinson's disease, preliminary results are promising.
The CBD has several therapeutic effects, which could potentially improve the symptoms of Parkinson's disease:
- Neuroprotective effect: through indirect stimulation of the Endocannabinoid System, different neuroprotective mechanisms are activated that combat inflammation and oxidative stress, benefiting motor and cognitive functions.
- Neuromodulatory effect: By stimulating dopaminergic receptors, CBD helps to regulate and increase dopamine levels, which promotes motor symptomatology and daily autonomy.
- Anti-inflammatory effect: By activating different channels, CBD reduces inflammation at the neurological, joint and muscle levels.
- Anxiolytic and antidepressant effect: CBD can improve mood and help manage emotional ups and downs.
- Relaxing effect: is important both physically and mentally, as it promotes muscle relaxation, rest and sleep.
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