The Bioavailability of CBD

CBD offers great health and healing benefits. Its high safety profile and non-addictive nature make it an attractive alternative to many conventional medicines.

But in order to be effective, CBD has to reach your endocannabinoid system. This means that it first has to be absorbed into the bloodstream, a concept known as bioavailability.

Once there, it has to remain in circulation long enough to reach the organs and tissues where it is needed.

Then, How much CBD is actually absorbed and used?

This depends on a process known as pharmacokinetics (how compounds are processed by the body).

In summary, pharmacokinetics refers to the sum of the mechanisms of absorption and elimination of your body, the characteristics of the body itself, the CBD and numerous external factors that can help or hinder the way in which you assimilate and use the CBD.

In addition, the route of entry, or method of administration, has much to do with the amount and speed with which the CBD enters the bloodstream.

 

CBD INGESTED (ORAL)

Bioavailability of CBD: What does it mean and why is it so important?

 can be incorporated into the coffee or the juice.

 

Oral formulations of CBD, such as the oils CBD, and other edibles, are among the most popular ways to consume CBD. CBDHowever, the Oral CBD has the lowest bioavailability of all forms of supply.On average, the CBD ingested has a bioavailability of between 6 and 19%.One of the reasons is that CBD not easily absorbed when ingested and, as a result, most of it is excreted without exerting any effect. This is due to the fact that CBD is fat-soluble (unlike water-soluble), which makes it challenging for the body to absorb.

In addition, acids and digestive enzymes destroy a large percentage of the CBD before it has a chance to be absorbed. And the small amount that does make it through the intestinal wall is subject to metabolism by the liver before reaching the rest of the body.

The half-life of the Oral CBDi.e. the time it takes for half of the CBD to exit the bloodstream, it may be faster than other methods of administration. It has been reported half-lives from 10 to 17 hours for high doses of between 750 mg and 1500 mg.

                                               CBD Ingested (oral)

Sublingual Drops (CBD Sublingual)

 
Drops of Sublingual CBD.

This method takes advantage of the capacity of the CBD to be absorbed directly through the mucous membranes of the mouth and nose, bypassing the digestive process and passing directly into the bloodstream.

The maximum levels The blood levels of this method, which consists of placing liquid drops of CBD under the tongue, have been measured in about two hours.

A simple way to improve the absorption of Sublingual CBD is to hold the drops under the tongue for 20-30 seconds before swallowing. This allows the mucous membranes more time to absorb the CBD before it enters the digestive tract.

                                                                                                                                   CBD Sublingual

CBD Topically (on the skin)

                                                             CBD applied in the form of topica

A scientific study suggests that the oil CBD can be beneficial for a number of different skin conditions. These may include:

Acne
Acne is the most common skin condition in humans. The CBD contains many compounds with oil-reducing, anti-inflammatory and antimicrobial properties that can help improve acne.

A study by 2014 explored the effects of CBD on human sebocytes. These are the cells that create sebum, which is a waxy, oily substance produced by the skin.

Although sebum helps protect our skin, excess sebum can also cause acne. The study suggests that CBD can prevent sebocytes from creating too much sebum.

A 2016 revision points to the possible antibacterial and antifungal properties of the cannabis plant. This could help prevent acne due to skin infections.

A 2019 study suggests that CBD may also be beneficial in treating the appearance of acne scars.

Learn more about CBD and acne here.

Dryness and itching

A 2019 study notes that CBD may be useful in treating some common symptoms of skin conditions, such as dryness and itching. The properties anti-inflammatory from CBD can be particularly helpful in reducing potential triggers of eczema, dermatitis and psoriasis.

As CBD oil can help soothe the skin and reduce the appearance of irritation, it may be useful for people with sensitive skin.

Learn more about CBD and psoriasis here.

Ageing and wrinkles
A 2017 study highlights the antioxidant properties of the CBD. Oxidative stressTrusted Source can contribute to the ageing process. Therefore, the properties antioxidants y anti-inflammatory CBD may help prevent the appearance of skin ageing.

Infection
As the cannabis plant may contain antibacterial properties and antifungal properties, it can be useful for treating skin infections.

Risks
According to the World Health Organisation (WHO), people generally tolerate CBD well. However, some common side effects of CBDwhich may be dose-dependent, may include

-mouthwashing
-somnolence
-fatigue
-diarrhoea
-changes in appetite and weight

                                                                                                                                 CBD on the skin

SOURCES:

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