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Is it safe to use CBD with other medicines?

Trust science, not us.

Nowadays, it is very common for people to take several natural compounds at the same time to achieve wellness. Given the influence of CBD in recent times and its effects on various biological systems, it is important to know if it can be taken with these chemical medications. Read on to learn all the necessary information.

Recent research shows that CBD has a very good safety record:

Ways continue to be discovered in which the CBD benefits the body, but one factor that remains constant is the compound's favourable safety record. CBD is very well tolerated and has minimal side effects. To give you a clearer picture, an average dose of Broad Spectrum CBD Oil is 3 to 4 drops 3 times a day, which equates to a total of approximately 40mg/day (based on the Balance Oil 10%CBD+1%CBG), until 170mg per day are well tolerated.

In addition, this compound has a very good safety profile, as recognised by the World Health Organisation after a in-depth analysis.

The relationship between CBD and medicines:

Cannabidiol, like many other molecules we consume on a daily basis, is metabolised by the liver before it becomes accessible to the whole body. After the digestive system has processed it, CBD undergoes a preliminary procedure in the liver. The liver uses special enzymes to break down CBD into small basic compounds called primary metabolites and distribute them throughout the body via the circulatory system. This process is perfectly natural, and happens in a similar way to how vitamins are broken down.

The problem that CBD can pose is when it is taken with other drugs, as it takes up almost all of the liver's attention. The special enzymes we have mentioned, namely cytochrome P450, are distracted by CBD, and this can prevent them from breaking down any other drugs present. This is where adverse effects can occur. If certain drugs stay in the body longer than necessary, the body may experience side effects.

Research on CBD-drug interactions continues

Any drug that is metabolised by the P450 enzyme could be affected by CBD. Many steroids, antibiotics, antidepressants, antihistamines and beta-blockers fall into this category. But just because these kinds of drugs are metabolised in the liver, it does not mean that interaction with CBD will definitely occur. When deciding to take CBD, you should consult a doctor first, especially if you are concerned about its effect on the medications you are taking.


Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in Anxiety and Sleep: A Large Case Series. Perm J. 2019;23:18-041. doi: 10.7812/TPP/18-041. PMID: 30624194; PMCID: PMC6326553.

Brown JD, Winterstein AG. Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use. J Clin Med. 2019 Jul 8;8(7):989. doi: 10.3390/jcm8070989. PMID: 31288397; PMCID: PMC6678684.

Antoniou T, Bodkin J, Ho JM. Drug interactions with cannabinoids. CMAJ. 2020 Mar 2;192(9):E206. doi: 10.1503/cmaj.191097. PMID: 32122975; PMCID: PMC7055953.

Iffland K, Grotenhermen F. An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis Cannabinoid Res. 2017 Jun 1;2(1):139-154. doi: 10.1089/can.2016.0034. PMID: 28861514; PMCID: PMC5569602.

Written by:
Carlos Vera

Carlos Vera

CEO & Founder

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