CBD and Epilepsy: Can CBD Oil Help Control Seizures?
CBD (cannabidiol) has gained significant attention in the scientific and medical community for its potential in the treatment of various conditions, including epilepsy . Recent research has shown promising results regarding the use of CBD oil in reducing the frequency and severity of seizures, especially in cases of refractory epilepsy, i.e., epilepsy that is resistant to traditional treatments.
In this article, we explore the science behind CBD and its effectiveness in treating epilepsy , reviewing recent clinical studies and cases where CBD has shown a positive impact on patients with seizures.
What is CBD and how does it work in the brain?
CBD is one of the most studied compounds in hemp and marijuana. Unlike THC , CBD has no psychoactive effects, meaning it doesn't cause the "high" associated with marijuana use. CBD interacts with the body's endocannabinoid system, which plays a key role in regulating functions like pain, mood, sleep, and, most importantly, neurological activity .
The role of the endocannabinoid system in epilepsy
The endocannabinoid system is composed of cannabinoid receptors (CB1 and CB2) found in the brain and other parts of the body. This system is believed to help regulate electrical activity in the brain, and dysfunctions in this system can contribute to seizures and epilepsy . CBD acts indirectly on these receptors, regulating neuronal excitability and reducing seizure frequency.
Scientific evidence of CBD for the treatment of epilepsy
Clinical studies on the use of CBD in epilepsy
One of the most significant studies on CBD and epilepsy was a 2017 clinical trial published in the New England Journal of Medicine . This study focused on children with Dravet syndrome, a severe form of childhood epilepsy that is difficult to treat with conventional medications. The study results showed that those receiving CBD oil experienced a 39% reduction in seizure frequency compared to 13% in the placebo group.
Another study, conducted on patients with Lennox-Gastaut syndrome , another severe form of childhood epilepsy, also showed encouraging results. Participants taking CBD significantly reduced the tonic and atonic seizures characteristic of this condition.
Approval of CBD-based medicines
In 2018, the US Food and Drug Administration ( FDA ) approved the first CBD -based medication, Epidiolex , specifically for the treatment of Dravet and Lennox-Gastaut syndromes. This approval marks an important milestone in the scientific and clinical validation of CBD 's use in the management of epilepsy .
How is CBD used to treat epilepsy?
The use of CBD oil for epilepsy can vary depending on the severity of the seizures and the patient's response to treatment. Below are common ways epilepsy patients use CBD :
1. Sublingual CBD oil
CBD oil is the most common and effective method. It's administered by placing a few drops under the tongue, where it's quickly absorbed into the bloodstream. This allows CBD to interact with receptors in the brain quickly and efficiently.
2. CBD capsules
CBD capsules provide a consistent and precise dose. These are ideal for those looking for a simple and convenient method of administration.
3. Edible CBD products
Some patients prefer edible CBD products , such as gummies or chocolates. Although this method may take longer to take effect, it can be helpful for patients who need around-the-clock seizure control.
Why is CBD oil effective for seizures?
CBD has been shown to be effective in reducing abnormal electrical activity in the brain, which is one of the primary causes of seizures. Its ability to modulate GABA and glutamate receptors—key neurotransmitters in neuronal excitation—makes it a potentially effective compound for reducing the excitability that can cause seizures.
Additionally, studies have shown that CBD has neuroprotective properties, meaning it not only helps reduce the frequency of seizures, but may also protect the brain from long-term damage associated with epilepsy .
Conclusion
The use of CBD for the treatment of epilepsy has shown promising results, especially in cases of epilepsy resistant to conventional treatments. Scientific studies have supported the effectiveness of CBD oil in reducing the frequency and intensity of seizures, particularly in Dravet and Lennox-Gastaut syndromes.
However, while CBD can be a useful complementary treatment, it should always be used under the supervision of a physician, especially when combined with other epilepsy medications. CBD is not a cure, but it can significantly improve the quality of life for many people suffering from this condition.
CBD products are not medications and cannot diagnose, treat, or cure any disease. Always consult your doctor before starting use.